莱斯特城客场球衣 www.qraeal.com.cn 高分辨率活细胞生物成像的最佳选择

LiT LBS激光片层扫描显微镜将帮助生物学家以前所未有的灵敏度，分辨率以及成像速度解读活体样品的三维动态过程。 Litone I．BS系统使用了最前沿的光学和工程技术来产生一束超薄的线性贝塞尔片层光（ Line Bessel Sheet，简称LBS），并用它来实现对生物样品的高精度光学层析。此项专利技术的应用不仅显著提高了片层光显微系统的成像分辦率，而且允许系统使用超弱的激发光便可从样品中获得足够的信号强度，所以极大的减弱了样品在成像时承受的光毒性，延长了样品的有效观测时间，以此帮助观测者获得更多高质量的成像数据。

LIT LBS激光片层扫描显微系统
开创了活细胞五维生物成像的时代
3维空间＋1维时间＋1维颜色

超越激光共聚焦显微技术

超越传统激光片层扫描显微技术

光毒性减弱1000倍

动态拍摄速度提高1000倍

轴向分辨率提高2倍

高速活细胞成像

拍摄速度可达500幅每秒
 

高分辨率三维结构成像
250nm横向分辨率
350nm轴向分辨率

部分参考文献： 

• 2018

• Sze Cheung Lau, Hoi Chun Chiu, Luwei Zhao, Teng Zhao, M. M. T. Loy, and Shengwang Du, “An integrated single- and two-photon non-diffracting light-sheet microscope,” Rev. Sci. Instrum. 89, 043701(2018); arXiv:1712.02521 [physics.ins-det].

•  Aifang Cheng, Teng Zhao, Kai-Hei Tse, Hei-Man Chow, Yong Cui, Liwen Jiang, Shengwang Du, Michael M. T. Loy, and Karl Herrup, “ATM and ATR play complementary roles in the behavior of excitatory and inhibitory vesicle populations,” Proc. Natl. Acad. Sci. USA (PNAS) 115, E292 (2018).
  [HKUST Press Release: “HKUST Scientists Reveal How Human Brains Keep Balance“]2017

• 2017

• Franco K. C. Au, Yue Jia, Kai Jiang, Ilya Grigoriev, Bill K. T. Hau, Yuehong Shen, Shengwang Du, Anna Akhmanova, and Robert Z. Qi, “GAS2L1 is a centriole-associated protein required for centrosome dynamics and disjunction,” Developmental Cell 40, 81 (2017)

• Huiqin Huang, Xiaochen Lin, Zhuoyi Liang, Teng Zhao, Shengwang Du, Michael M. T. Loy, Kwok-On Lai, Amy K. Y. Fu, and Nancy Y. Ip, “Cdk5-dependent phosphorylation of liprinα1 mediates neuronal activity-dependent synapse development,” Proc. Natl. Acad. Sci. USA (PNAS) 114, E6992 (2017)

• 2016

•  Hao Wang* Visualizing Plant Cells in A Brand New Way. Molecular Plant 9, 633-635(2016).

• Graham Vail, Aifang Cheng, Yu Ray Han, Teng Zhao, Shengwang Du, Michael M.T. Loy, Karl Herrup, and Mark R. Plummer, “ATM protein is located on presynaptic vesicles and its deficit leads to failures in synaptic plasticity,” J. Neurophysiol. 116, 201 (2016) 

• Hao Wang, Xiaohong Zhuang, Xiangfeng Wang, Angus Ho Yin Law, Teng Zhao, Shengwang Du, Michael M. T. Loy, and Liwen Jiang, “A distinct pathway for polar exocytosis in plant Cell wall formation1“, Plant Physiology 172, 1003 (2016) 

• Teng Zhao, Sze Cheung Lau, Ying Wang, Yumian Su, Hao Wang, Aifang Cheng, Karl Herrup, Nancy Y. Ip, Shengwang Du, and M. M. T. Loy, “Multicolor 4D fluorescence microscopy using ultrathin Bessel light sheets,” Sci. Rep. 6, 26159 (2016).